Clenbuterol Review, Results, & Guide For Bodybuilding 2025

For these experiments, we used transgenic mice that expressed a dominant-negative version of AMPK under the transcriptional control of the muscle-specific MCK promoter (MCK-AMPK-DN)39. Remarkably, as observed with the SKM-Rictor-KO mice (Fig.5a, b), the ability of clenbuterol treatment to improve glucose tolerance was nearly abolished in the MCK-AMPK-DN mice (Supplementary Fig. 10t, u). Athletes, bodybuilders, and others who use clenbuterol do so for its ability to burn fat, build muscle, and improve sports performance. The drug is believed to increase skeletal muscle development by enhancing muscle protein synthesis. At the same time, it aids in fat loss by increasing resting energy expenditure and fat oxidation. In the present study, clenbuterol treatment significantly affected the inhibitory phosphorylation of GS (pGS) (Supplementary Fig. 10a, b), based on glucose availability.

And it is different from Urology, a surgical specialty that does not focus on the common medical aspects of how androgens effect men. In regards to the side effects, it’d be best to to get a check-up by your doctor to make sure you’re in good health; and then to be monitored throughout your cycle to make sure your blood pressure is within a normal range. It’s also worth noting that with clen you won’t have to worry about low testosterone or infertility post-cycle as it doesn’t shut you down like anabolic steroids do.

• HGH is one of the reasons bodybuilders today are the biggest and most shredded in the history of IFBB, as this is a newly discovered drug.
• It’s popular with bodybuilders and athletes because it is rumored to build muscle and promote fat loss, says Jena Brown, R.D., C.S.S.D., owner of Victorem Performance Nutrition.
• Three-time Tour de France winner Alberto Contador may be the most famous athlete to have used this excuse after testing positive for clenbuterol.
• This is because clenbuterol acts similar to adrenaline in the body (activation of the sympathetic nervous system).
• Therefore, the use of clenbuterol has become popular among athletes, bodybuilders, and gym enthusiasts.
• T3 is another compound used for fat burning, which is often stacked with Clenbuterol.

Focus on a holistic approach, as long-term success lies in gradual, healthy transformations rather than quick fixes with potential side effects. Also, people with high blood sugar may experience symptoms of abnormal sweating and feel warmer than usual. These cardiovascular side effects can lead to heart enlargement, or cardiac hypertrophy, which raises the risk of a heart attack and stroke. According to research by NIH, acute clenbuterol overdose resulting in low serum potassium concentrations occurs when this substance stimulates the adrenergic nervous system (ANS), allowing extracellular potassium to enter cells 6.

Clenbuterol for Bodybuilders

Also clen’s ability to burn fat can help make an athlete more functional due to weighing less (especially advantageous in endurance sports). I’ve performed clen cycles for many years now, and people always ask me questions about this drug; so this article is dedicated to helping others understand the pros and cons of clen. This research was funded by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, NIH). We thank Kristopher W. Krausz (NCI, NIH) for assistance with the mass spectrometry studies and Dr. Frank J. Gonzalez (NCI, NIH) for helpful advice and support of this work.

However, we find users commonly experience a crash with low energy after this initial effect wears off, consequently creating a dependence on clenbuterol. Thus, clenbuterol may help bodybuilders retain muscle when cutting, although significant increases in muscle size and strength are unlikely in our experience. This is therefore more of an anti-catabolic effect than an anabolic one. Some interesting research suggests clenbuterol use could have merit in diabetes management.

What is Clenbuterol? (Everything You Need To Know)

It’s believed that it may work best as liquid drops, as it enters your system quicker. Dairy products can have the opposite effect when it comes to water in the body, often causing it to hold in all the wrong places making you look bigger than you are. Excessive consumption of high-sugar foods and sweetened drinks have been linked to weight gain, as theyare a major (and unnecessary) source of calories, which have no nutritional value.

During this 5-day period, mice consumed 3.5 ± 0.06 ml of clenbuterol water per day, resulting in an average clenbuterol dose of 104.7 ± 1.2 μg per mouse per day. For chronic clenbuterol studies performed with transgenic mice, baseline ipGTTs were performed with control and the indicated KO PCT in USA mice as described above. Two days later, both control and mutant mice started to consume clenbuterol drinking water. After 5 days on clenbuterol water, mice were subjected to another ipGTT. AMPK and mTORC2-dependent signaling pathways differentially regulate Plin3 expression38.

Taken together, these data further corroborate the central role of SKM β2-AR/Gαs signaling in meditating the metabolic effects caused by systemic administration of a β2-AR agonist. Metabolomic analysis indicated that clenbuterol-treated mice showed increased levels of SKM acylcarnitines (e.g., malonylcarnitine), as compared to control animals that had not received clenbuterol (Fig. 4f). Next, we treated SKM-β2-AR-KO and SKM-Gs-KO mice for 5 days with clenbuterol (via the drinking water). Remarkably, in the absence of SKM β2-ARs or SKM Gαs, the ability of clenbuterol treatment to improve glucose tolerance was abolished (Fig. 1g, h). These data clearly indicate that clenbuterol administration improves whole-body glucose homeostasis by stimulation of SKM β2-ARs and subsequent activation of SKM Gs.